STUDIES & RESEARCH

Nicotinamide adenine dinucleotide (NAD+): essential redox metabolite, co-substrate and an anti-cancer and anti-ageing therapeutic target

by Hollie B.S. Griffiths, Courtney Williams, Sarah J. King, Simon J. Allison

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Reynolds et al. (2021)

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This study reports that mitochondrial-encoded MOTS-c can significantly enhance physical performance in young (2 mo.), middle-age (12 mo.), and old (22 mo.) mice. MOTS-c can regulate (i) nuclear genes, including those related to metabolism [...]